Trent Edwards got sacked and missed a big part of the game against the Cardinals, and so the Bills looked weaker and missed their first match and lost their undefeated 4-0 record.
J.P. Losman replaced Edwards, and in despite of not playing that bad, he lacked chemistry with his teammates and so defeat was served.
Arizona beat the collectively numb Bills by 41-17 and improved their record to 3-2.
Now Buffalo has their bye week, which is enough time to prepare to play the Chargers on Week 7.
The Bills are still heading the AFC East with one more victory than the Patriots, whom are playing San Diego on Week 6, so in order to remain at the top of their division, Buffalo might be praying for another loss for New England.
